Endocrine Abstracts

Background: Among the heterogeneous types of diabetes mellitus (DM), latent autoimmune diabetes in adults (LADA) is the most common and attracts the attention of scientists, the pathogenesis of which combines the main mechanisms of classical type 1 (T1DM) and type 2 diabetes mellitus (T2DM). The role of hyperamylinemia in the development and progression of LADA remains out of the researchers’ attention.The objective: of the study was to determine th...

Background: Chronic kidney disease (CKD) is one of the leading causes of disability and mortality in patients with different types of diabetes mellitus (DM). However, relationships between kidney function and serum amylin levels are still controversial, especially in patients with heterogeneous types of diabetes. The objective of the study was to determine the features of the glomerular filtration rate (GFR) in patients with DM depending on the level of amylinemia.<p class...

Background: Metabolic syndrome is a cluster of conditions (abdominal obesity, atherogenic dyslipidemia, hypertension, insulin resistance with or without glucose intolerance) that occur together, increasing risk of cardiovascular diseases.The objective: Of the study was to determine components of metabolic syndrome in patients with diabetic kidney disease (DKD) depending on the phenotype of LADA.Methods: 42 patients with LADA (19 pa...

Background: Chronic pyelonephritis (CP) is a common kidney infection complication in patients with diabetes mellitus and one of the main reasons of chronic kidney disease in diabetic patients.The objective: Of the study was to determine the features of the carbohydrate metabolism and insulin resistance in patients with CP depending on the phenotype of latent autoimmune diabetes in adults (LADA).Methods: 28 patients with LADA and CP...

IntroductionVitamin D deficiency is recognized as a global problem worldwide. Today, there is information about the relationship between vitamin D levels and the pathogenetic links in the development of classic forms of diabetes mellitus (DM). In particular, vitamin D deficiency has been shown to cause insulin deficiency, progression of insulin resistance, and β-cell dysfunction. There is growing evidence that vitamin D deficiency may be a risk fact...

Introduction: Decrease in thyroid hormones (TH) levels is associated with reduced blood flow to kidneys and decreased glomerular filtration rate (GFR) along with alteration of tubular reabsorption.Deiodinase type 1 is an enzyme that is active in liver and kidneys and plays an important role in TH metabolism.The aim of the research was to study the dependence of markers of renal function on C/T polymorphism in the DIO 1 gene in pati...

Introduction: Chronic kidney disease (CKD) is one of the leading causes ofdisability and mortality in patients with diabetes mellitus. Existence of specific phenotypes of diabetic kidney disease (DKD) is established nowadays. The prevalence of the classic albuminuric phenotype has decreased by 24% over the past decade (NHANES).The purpose of our work was to investigate the phenotypic features of DKD depending on the type of diabetes.<p class="abstext...

Introduction: In order to improve the early diagnostics of cholelithiasis in patients with chronic acalculous cholecystitis combined with diabetes mellitus type 2 (DM), individual parameters are usually not sufficient. Therefore, we decided to establish and analyze the correlation between the serum and biochemical parameters of bile to evaluate biochemical connections in a system of lipid homeostasis by comorbid pathology. The aim of our study was to determine the peculiaritie...

Introduction: Thyroid hormones affect sex hormone metabolism and reproductive function in women. Infertility in women with autoimmune thyroiditis is more difficult to treat than in women with normal thyroid function. On the other hand, immune factors are dependent on exogenous and endogenous factors, interrelated with hormones and are important regulators of fertility, autoimmune reactionsand can lead to infertility and increase the risk of pregnancy complications and miscarri...

Introduction: The prevalence of manifest hypothyroidism by various data is 0.2–2%, sub-clinical – up to 3% in men and up to 10% in women, and in people over 70 years old – 13–14%. The presence of concomitant gastrointestinal diseases significantly limits the possibility of hypothyroidism compensation; these patients need higher doses of levothyroxine. According to a number of researchers, hypothyroidism is often accompanied by small intestinal bacterial...